Measures of Local Retinal Damage with Multifocal ERG

How can we use mfERG to track diseases and damage of the macula?

The mfERG is now widely used to diagnose and study diseases of the macula. While the technique was invented and developed by Erich Sutter, it is generally accepted that we were key in demonstrating and exploring its use in the clinic and the laboratory. The 2000 review (ref 1 below) has been cited over 450 times to date, although many more individuals have used this as their introduction to the mfERG. Our contributions to our understanding of the mfERG are summarized in numerous studies over the last 15 years; these studies have been cited over 1800 times. As in the case of the a-wave analysis, we have made our analysis software available to others.

The mfVEP can be used to objectively measure visual fields in patients with glaucoma, optic neuritis/multiple sclerosis (MS), as well as in patients suspected of non-organic causes of visual field loss. Again, although the mfVEP was first proposed by Erich Sutter, we and a group in Australia (Graham and Klistorner) have done the work to make this a clinically useful technique. While this work thus far has had less of an impact than our a-wave and mfERG work, it has a following among a number of prominent neuro-ophthalmologists and has been cited over 1400 times. It is likely to be THE way to follow the treatment of optic neuritis secondary to MS. Again, our free software is being used by a number of laboratories working with the mfVEP.